Research and Development

Research & Development

IVS is one of the UK’s leading companies for vascular imaging innovation and development. In collaboration with medical physicists, surgeons and nurses our vascular scientists work closely with industry experts from the field of medicine, surgery, pharmaceuticals and medical imaging to continually develop new diagnostics and minimally invasive vascular technologies.

We have supported several commercial and academic studies over the past 15 years with numerous high-ranking publications. Our state of the art and welcoming labs are fully equipped to accommodate a variety of research studies including first-in-man and randomised control trials.

We are always receptive to innovating and interesting research projects. Drop us an email!

 

Our Equipment:

Ultrasound: Mindray – Resona7 and M9, Philips – Epiq and Affiniti 

Trans Cranial Doppler machine – Doppler Box DWL

Laser Speckle Contrast Imager – Moor instruments FLPI-2.

 

Our Research Team:

Current IVS commercial studies:

Current IVS Academic Studies:

Horizon 2020:

We are currently involved in a number of exciting and cutting edge research projects using tomographic 3D ultrasound technology, which can potential replace expensive imaging technologies such as computed tomography (CT), magnetic resonance (MR) and digital subtraction angiography (DSA) for some vascular indications with the same or better diagnostic accuracy.

 

As part of a consortium of five international partners. IVS Ltd along with PIUR imaging GmbH, The University of Manchester, ACMIT and Imfusion GmBH have recently been awarded a €2.1 million Horizon 2020 research grant from the European Commission. The H2020 project aims to develop tomographic ultrasound with four large studies running in some of our NHS sites: Carotid Plaque Volume, Peripheral Arterial Disease, Conduit mapping and Arterio-Venous Fistula Studies.

 

 

 

Previous studies:

CHAMPion Study (academic)

We have just finalised the CHAMPion study, a large investigation assessing patients with colorectal cancer undergoing surgery. A DVT scan was performed with the intent to identify clots. Some evidence demonstrates that patients who develop deep vein thrombosis or pulmonary embolism during their cancer treatment have more aggressive cancers. Our scans enabled surgeons to identify that the rate of asymptomatic and undiagnosed DVT was higher that the recorded literature. Something which will influence the medical management of this patient group in future.

ROUGE Study (academic)

3D Temporal arteritis - measuring the arterial wall volume in the temporal artery for diagnosis of temporal arteritis using tomographic ultrasound. This will be a beneficial study as currently diagnosis is made via a biopsy of the temporal artery.

 

VisualSonics Vevo MD (commercial)

We recently have had the opportunity to work with a new ultra-high frequency ultrasound system brought to the market by VisualSonics. This system is the first-in-man machine that utilises probes at 48 MHz and 70 MHz transducers with high resolution ultrasound images that allowed us to visualise small vessels such as the finger arteries or capillary bed. It is best to think of this like ultrasound microscopy and allows the detection and measurement of disease not previously identified on standard ultrasound. IVS have worked with VisualSonics to improve the system for the vascular market.

Scleroderma (academic)

2D and 3D Scleroderma - measuring intima-medial thickening and total vessel wall volume of the second finger proper digital arteries as a feasibility study in patients diagnosed with scleroderma using tomographic ultrasound and the VisualSonics system.

Migraine (commercial)

We recently have loaned our TCD machine along with providing training and protocol revision to MAC at CityLabs, Manchester to assess patients with migraines. The aim was to test current and new drug responses for treating migraine.

REVACEPT (commercial)

2D carotid and TCD scans on patients with a post-ischemic event to evaluate a drug response to the incidence of micro embolic signals (MES) before carotid endarterectomy.

Rotational Angio VS CEtUS for EVAR completion imaging (academic)

Use of contrast enhanced tomographic ultrasound compared to rotational angiography for completion imaging following deployment of EVAR stent graft in theatre.

 

(Left: 3D reconstruction from rotational 2D projection X-ray angiography with no endoleak, Middle: 3D volume of X-ray angiography with no endoleak, Right: 3D CEtUS volume with a type IIb endoleak from the same patient.)

 

Palmer Arch Mapping (academic)

 

 

Publications:

Research Partners:

                                 

 

 

IVS Diagnostic

Can save 17% to 34% of the cost of setting up and running a vascular laboratory

Reduces capital expenditure

Lowers staff and administration costs

95% of inpatients investigated the same day

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0161 998 2626

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