Research and Development
Research & Development
IVS is one of the UK’s leading companies for vascular imaging innovation and development. In collaboration with medical physicists, surgeons and nurses our vascular scientists work closely with industry experts from the field of medicine, surgery, pharmaceuticals and medical imaging to continually develop new diagnostics and minimally invasive vascular technologies.
We have supported several commercial and academic studies over the past 15 years with numerous high-ranking publications. Our state of the art and welcoming labs are fully equipped to accommodate a variety of research studies including first-in-man and randomised control trials.
We are always receptive to innovating and interesting research projects. Drop us an email!
Ultrasound: Mindray – Resona7 and M9, Philips – Epiq and Affiniti
Trans Cranial Doppler machine – Doppler Box DWL
Laser Speckle Contrast Imager – Moor instruments FLPI-2.
Our Research Team:
- - Mr. Steven Rogers – Senior Vascular Scientist & Research Manager
- - Mr. Joao Carreira – Clinical Vascular Scientist & Research Associate
- - Mrs. Ruth Thompson – Clinical Vascular Scientist
- - Miss. Louise Bowen – Clinical Vascular Scientist
- - Mrs Kate Simm - Clinical Vascular Scientist
Current IVS commercial studies:
- GEKO 1/ GEKO 2 studies – 2D scans of popliteal vein blood flow assessment to evaluate the acute effect of an electro nerve stimulation device at the peroneal nerve in patients with venous leg ulcers.
- GE CONTRAST study - scanning EVAR on patients with stage 3 and 4 renal failure compared to a new type of CT contrast agent.
- MEDTRONIC VENASEAL – 2D venous scans of lower limbs after endovascular treatment of varicose veins responsible for calf ulceration.
Current IVS Academic Studies:
- Neuro-stimulation – 2D scans assessing the arterial blood flow of the lower limbs in order to develop a new neuro-stimulation treatment for patients with limited surgical options to aid extending leg salvage in those with Critical Limb Ischemia.
- CADAS – 3D tomographic ultrasound scans of patients with a full cerebral vascular accident who do not fill the category for endarterectomy.
- Cardiac SVT ablation DVT prevalence – DVT scans of patients that had ablation following Supraventricular tachycardia.
- Palmar Arch Mapping – 3D tomographic ultrasound scans of the anatomical vasculature of the hands to try and identify the superficial Palmer arch type.
- Intimal Thickening – 3D tomographic ultrasound scans of the IMT. A measuring tool to detect early arterial disease.
- AAA and EVAR growth assessment – 3D tomographic scans of patients with AAA and EVAR in an attempt to predict abdominal aortic aneurysm growth.
We are currently involved in a number of exciting and cutting edge research projects using tomographic 3D ultrasound technology, which can potential replace expensive imaging technologies such as computed tomography (CT), magnetic resonance (MR) and digital subtraction angiography (DSA) for some vascular indications with the same or better diagnostic accuracy.
As part of a consortium of five international partners. IVS Ltd along with PIUR imaging GmbH, The University of Manchester, ACMIT and Imfusion GmBH have recently been awarded a €2.1 million Horizon 2020 research grant from the European Commission. The H2020 project aims to develop tomographic ultrasound with four large studies running in some of our NHS sites: Carotid Plaque Volume, Peripheral Arterial Disease, Conduit mapping and Arterio-Venous Fistula Studies.
- 3D carotid plaque volume - quantitative evaluation of carotid plaque volume as an assessment of plaque vulnerability for stroke prediction.
- 3D peripheral arterial disease -
- visualisation of occlusion or stenosis in the calf or foot for surgical and endovascular option planning without the need for CTA, MRA or DSA.
- 3D Arterio-venous Fistula – rapid visualisation of occlusion or stenosis in arterio-venous fistula with limited experience.
- 3D Conduit mapping for bypass surgery – rapid visualisation of potential vessels to utilise for cardiac or vascular bypass.
CHAMPion Study (academic)
We have just finalised the CHAMPion study, a large investigation assessing patients with colorectal cancer undergoing surgery. A DVT scan was performed with the intent to identify clots. Some evidence demonstrates that patients who develop deep vein thrombosis or pulmonary embolism during their cancer treatment have more aggressive cancers. Our scans enabled surgeons to identify that the rate of asymptomatic and undiagnosed DVT was higher that the recorded literature. Something which will influence the medical management of this patient group in future.
ROUGE Study (academic)
3D Temporal arteritis - measuring the arterial wall volume in the temporal artery for diagnosis of temporal arteritis using tomographic ultrasound. This will be a beneficial study as currently diagnosis is made via a biopsy of the temporal artery.
VisualSonics Vevo MD (commercial)
We recently have had the opportunity to work with a new ultra-high frequency ultrasound system brought to the market by VisualSonics. This system is the first-in-man machine that utilises probes at 48 MHz and 70 MHz transducers with high resolution ultrasound images that allowed us to visualise small vessels such as the finger arteries or capillary bed. It is best to think of this like ultrasound microscopy and allows the detection and measurement of disease not previously identified on standard ultrasound. IVS have worked with VisualSonics to improve the system for the vascular market.
2D and 3D Scleroderma - measuring intima-medial thickening and total vessel wall volume of the second finger proper digital arteries as a feasibility study in patients diagnosed with scleroderma using tomographic ultrasound and the VisualSonics system.
We recently have loaned our TCD machine along with providing training and protocol revision to MAC at CityLabs, Manchester to assess patients with migraines. The aim was to test current and new drug responses for treating migraine.
2D carotid and TCD scans on patients with a post-ischemic event to evaluate a drug response to the incidence of micro embolic signals (MES) before carotid endarterectomy.
Rotational Angio VS CEtUS for EVAR completion imaging (academic)
Use of contrast enhanced tomographic ultrasound compared to rotational angiography for completion imaging following deployment of EVAR stent graft in theatre.
(Left: 3D reconstruction from rotational 2D projection X-ray angiography with no endoleak, Middle: 3D volume of X-ray angiography with no endoleak, Right: 3D CEtUS volume with a type IIb endoleak from the same patient.)
Palmer Arch Mapping (academic)
- Ball S., Rogers S., Kanesalingam K., Taylor R., Katsogridakis E. and McCollum C.
- Carotid plaque volume in patients undergoing carotid endarterectomy. British Journal of Surgery 2018, (Ipub ahead of print)
- Al-Jarrah, Q., Ashrafi, M., Oldbury, J., Rogers, S., Baguneid, M. & Wolowczyk, L. Surgical management of a symptomatic extracranial internal carotid artery aneurysm and coexisting carotid body tumor. Journal of Vascular Surgery Cases 2015, 1(2), 134-137.
- Lowe, C., Abbas, A., Rogers, S., Smith, L., Ghosh, J. & McCollum, C. Three-dimensional contrast-enhanced ultrasound improves endoleak detection and classification after endovascular aneurysm repair. Journal of Vascular Surgery 2017.
- Lowe, C., Abbas, A., Rogers, S., Smth, L., Ghosh, J. & McCollum, C. (2016a). Three-Dimensional Contrast-Enhanced Ultrasound Improves the Detection and Classification of Endoleaks Following Endovascular Aneurysm Repair. European Journal of Vascular and Endovascular Surgery 2016a, 52(3), 412.
- Lowe, C., Ghulam, Q., Bredahl, K., Rogers, S., Ghosh, J., Sillesen, H., McCollum, C. N. & Eiberg, J. (2016b). Three-dimensional Ultrasound in the Management of Abdominal Aortic Aneurysms: A Topical Review. Eur J Vasc Endovasc Surg 2016b, 52(4), 466-474.
- Owen, B., Lowe, C., Ashton, N., Mandal, P., Rogers, S., Wein, W., McCollum, C. & Revell, A. (2016). Computational hemodynamics of abdominal aortic aneurysms: Three-dimensional ultrasound versus computed tomography 2016. Proc Inst Mech Eng H, 230(3), 201-10.
✓ Can save 17% to 34% of the cost of setting up and running a vascular laboratory
✓ Reduces capital expenditure
✓ Lowers staff and administration costs
✓ 95% of inpatients investigated the same day
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